Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 2/20 | 0.47 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013987 | 0.84 | HTR1F (0.47) | HTR1FNOS3NOS1SLC6A4KDM4E | |
| SCHEMBL7004488 | 0.82 | HTR1F (0.48) | HTR1FNOS3NOS1SLC6A4KDM4E | |
| SCHEMBL7012389 | 0.81 | HTR1F (0.50) | HTR1FNOS3NOS1SLC6A4KDM4E | |
| SCHEMBL7012929 | 0.80 | HTR1F (0.51) | HTR1FNOS3NOS1SLC6A4KDM4E | |
| SCHEMBL7009277 | 0.79 | NOS3 (0.48) | HTR1FNOS3NOS1SLC6A4POLB | |
| SCHEMBL7016665 | 0.79 | HTR1F (0.48) | HTR1FNOS3NOS1SLC6A4KDM4E | |
| SCHEMBL7013676 | 0.79 | HTR1F (0.46) | HTR1FNOS3NOS1SLC6A4KDM4E | |
| SCHEMBL7013047 | 0.79 | SLC6A4 (0.49) | HTR1FNOS3NOS1SLC6A4KDM4E | |
| SCHEMBL7008777 | 0.77 | HTR1F (0.58) | HTR1FHTR1AHTR6 | |
| SCHEMBL7012793 | 0.76 | HTR1F (0.76) | HTR1FSLC6A4KDM4ELMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0916670-B1 | Pyrrolo-(3,2-b) pyridines and their use as 5-HT1F agonists | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-0916670-A2 | Pyrrolo-(3,2-b) pyridines and their use as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1999-05-19 | — | — | EP | disclosed |
| US-5905084-A | 5-SUBSTITUTED-3-(PIPERIDIN-4-YL)- AND -3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)PYRROLO(3,2-B)PYRIDINES; SIDE EFFECT REDUCTION; NERVOUS SYTEM AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY (US) | 1999-05-18 | — | — | US | disclosed |