Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 7/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.40 |
| ▸ | ATP4A | P20648 | 3/20 | 0.36 |
| ▸ | ATP4B | P51164 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011801 | 0.88 | PLA2G1B (0.45) | PLA2G1BGRM2ATP4AATP4BMEN1 | |
| SCHEMBL8322218 | 0.87 | PLA2G1B (0.38) | PLA2G1BATP4AATP4BMEN1KMT2A | |
| SCHEMBL7006126 | 0.87 | PLA2G1B (0.46) | PLA2G1BGRM2ATP4AATP4BMEN1 | |
| SCHEMBL7012019 | 0.84 | PLA2G1B (0.38) | PLA2G1BGRM2ATP4AATP4BMEN1 | |
| SCHEMBL7014264 | 0.82 | PLA2G1B (0.42) | PLA2G1BATP4AATP4BMEN1CYP1A2 | |
| SCHEMBL7011597 | 0.78 | ATP4A (0.44) | PLA2G1BATP4AATP4BMEN1CYP1A2 | |
| SCHEMBL7013502 | 0.77 | PLA2G1B (0.70) | PLA2G1B | |
| SCHEMBL7006186 | 0.75 | PLA2G1B (0.48) | PLA2G1BATP4AATP4BMEN1CYP1A2 | |
| SCHEMBL7014249 | 0.74 | ATP4A (0.40) | PLA2G1BATP4AATP4BMEN1CYP1A2 | |
| SCHEMBL7013631 | 0.74 | ATP4A (0.42) | PLA2G1BATP4AATP4BMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |