Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ATP4A | P20648 | 1/20 | 0.35 |
| ▸ | ATP4B | P51164 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014370 | 0.87 | PLA2G1B (0.41) | PLA2G1BMEN1KMT2AATP4AATP4B | |
| SCHEMBL7012019 | 0.83 | PLA2G1B (0.38) | PLA2G1BNPC1MAPK8MAPK9MEN1 | |
| SCHEMBL7014264 | 0.78 | PLA2G1B (0.42) | PLA2G1BMEN1KMT2AATP4AATP4B | |
| SCHEMBL7013631 | 0.77 | ATP4A (0.42) | PLA2G1BNPC1MEN1KMT2ARAB9A | |
| SCHEMBL8321751 | 0.77 | L3MBTL1 (0.46) | PLA2G1BNPC1MEN1KMT2ARAB9A | |
| SCHEMBL7011801 | 0.76 | PLA2G1B (0.45) | PLA2G1BMEN1KMT2AATP4AATP4B | |
| SCHEMBL7006126 | 0.75 | PLA2G1B (0.46) | PLA2G1BMEN1KMT2AATP4AATP4B | |
| SCHEMBL7011597 | 0.74 | ATP4A (0.44) | PLA2G1BMEN1KMT2AATP4AATP4B | |
| SCHEMBL7009138 | 0.73 | ALDH1A1 (0.42) | PLA2G1BNPC1MAPK8MAPK9MEN1 | |
| SCHEMBL7013513 | 0.72 | SGMS2 (0.43) | PLA2G1BNPC1MAPK8MAPK9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |