Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014427 | 1.00 | MAPT (0.48) | MAPTFEN1KDM4EHTTPOLB | |
| SCHEMBL7015733 | 0.88 | FEN1 (0.50) | MAPTFEN1KDM4EHTTPOLB | |
| SCHEMBL7015737 | 0.88 | FEN1 (0.50) | MAPTFEN1KDM4EHTTPOLB | |
| SCHEMBL7017940 | 0.81 | KDM4E (0.41) | MAPTKDM4EHTTPOLBPKM | |
| SCHEMBL7017938 | 0.81 | KDM4E (0.41) | MAPTKDM4EHTTPOLBPKM | |
| SCHEMBL7022008 | 0.81 | ADRA1B (0.42) | KDM4ECYP1A2ALDH1A1ADRA1BPARP1 | |
| SCHEMBL7022004 | 0.81 | ADRA1B (0.42) | KDM4ECYP1A2ALDH1A1ADRA1BPARP1 | |
| SCHEMBL7016851 | 0.78 | ADORA2A (0.33) | KDM4EHTTPKMALDH1A1HSD17B10 | |
| SCHEMBL7022760 | 0.78 | ADORA3 (0.36) | KDM4EHTTPKMALDH1A1HSD17B10 | |
| SCHEMBL7016847 | 0.78 | ADORA2A (0.33) | KDM4EHTTPKMALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | disclosed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |