Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.63 |
| ▸ | TEK | Q02763 | 13/20 | 0.63 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7095826 | 0.94 | KDR (0.66) | KDRTEKMTOR | |
| SCHEMBL7099685 | 0.93 | KDR (0.73) | KDRTEK | |
| SCHEMBL5345825 | 0.91 | KDR (0.76) | KDRTEK | |
| SCHEMBL7017029 | 0.85 | KDR (0.65) | KDRTEKMTOR | |
| SCHEMBL5359514 | 0.85 | KDR (0.80) | KDRTEK | |
| SCHEMBL7012558 | 0.84 | KDR (0.55) | KDRTEKMTOR | |
| SCHEMBL7017943 | 0.84 | KDR (0.71) | KDRTEK | |
| SCHEMBL5347351 | 0.84 | KDR (0.87) | KDRTEK | |
| SCHEMBL5390357 | 0.84 | KDR (0.68) | KDRTEK | |
| SCHEMBL7015248 | 0.82 | KDR (0.54) | KDRTEKMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | claimed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | claimed |
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | disclosed |