Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.66 |
| ▸ | TEK | Q02763 | 8/20 | 0.66 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.48 |
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099685 | 0.95 | KDR (0.73) | KDRTEKTRPV1BRAF | |
| SCHEMBL7014470 | 0.94 | KDR (0.63) | KDRTEKMTOR | |
| SCHEMBL5359514 | 0.91 | KDR (0.80) | KDRTEK | |
| SCHEMBL5390357 | 0.90 | KDR (0.68) | KDRTEKTRPV1BRAF | |
| SCHEMBL5347351 | 0.87 | KDR (0.87) | KDRTEK | |
| SCHEMBL7017029 | 0.86 | KDR (0.65) | KDRTEKBRAFMTOR | |
| SCHEMBL5345825 | 0.85 | KDR (0.76) | KDRTEK | |
| SCHEMBL7015248 | 0.83 | KDR (0.54) | KDRTEKBRAFMTOR | |
| SCHEMBL5342331 | 0.83 | KDR (0.63) | KDRTEKMTOR | |
| SCHEMBL7017627 | 0.82 | KDR (0.51) | KDRTEKBRAFMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | claimed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | claimed |
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | disclosed |