Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.46 |
| ▸ | JAK2 | O60674 | 8/20 | 0.46 |
| ▸ | JAK1 | P23458 | 7/20 | 0.46 |
| ▸ | TTK | P33981 | 2/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015994 | 0.84 | NPY1R (0.44) | JAK3JAK2JAK1TTKNPY1R | |
| SCHEMBL7012500 | 0.78 | JAK2 (0.50) | JAK3JAK2JAK1TTKNPY1R | |
| SCHEMBL7016488 | 0.77 | JAK2 (0.48) | JAK3JAK2JAK1TTKNPY1R | |
| SCHEMBL7014469 | 0.76 | JAK3 (0.47) | JAK3JAK2JAK1TTKNPY1R | |
| SCHEMBL7019510 | 0.76 | NPY1R (0.45) | JAK3JAK2JAK1TTKNPY1R | |
| SCHEMBL7102412 | 0.76 | NPY1R (0.53) | JAK3JAK2JAK1TTKNPY1R | |
| SCHEMBL7010930 | 0.75 | NPY1R (0.46) | JAK3JAK2JAK1TTKNPY1R | |
| SCHEMBL7016400 | 0.75 | JAK2 (0.47) | JAK3JAK2JAK1TTKNPY1R | |
| SCHEMBL7019593 | 0.75 | NPY1R (0.49) | JAK3JAK2JAK1TTKNPY1R | |
| SCHEMBL7016700 | 0.74 | JAK2 (0.45) | JAK3JAK2JAK1TTKNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889034-B1 | AMINOPYRIDINE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2003-09-17 | — | — | EP | disclosed |
| US-6011039-A | USEFUL AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS; TREATING HYPERPHAGIA, OBESITY OR DIABETES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-01-04 | — | — | US | disclosed |
| EP-0889034-A1 | AMINOPYRIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-01-07 | — | — | EP | disclosed |