Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 1/20 | 0.48 |
| ▸ | SELE | P16581 | 1/20 | 0.48 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.48 |
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.46 |
| ▸ | PDE5A | O76074 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.42 |
| ▸ | TCF7L2 | Q9NQB0 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7021735 | 0.93 | HRH4 (0.47) | HRH4CTNNB1TCF7L2 | |
| SCHEMBL7019661 | 0.92 | ICAM1 (0.46) | ICAM1SELEVCAM1P2RY12PDE5A | |
| SCHEMBL7016359 | 0.89 | HRH4 (0.47) | PDE5AHRH4HTR3AHTR2ADRD3 | |
| SCHEMBL7013978 | 0.89 | PDE4A (0.43) | ICAM1SELEVCAM1P2RY12PDE5A | |
| SCHEMBL7016414 | 0.89 | PDE5A (0.41) | ICAM1SELEVCAM1P2RY12PDE5A | |
| SCHEMBL7015416 | 0.88 | ACHE (0.41) | P2RY12PDE5AHRH4KDM4EALDH1A1 | |
| SCHEMBL8181130 | 0.88 | ICAM1 (0.51) | ICAM1SELEVCAM1P2RY12PDE5A | |
| SCHEMBL7016253 | 0.88 | PDE4A (0.49) | ICAM1SELEVCAM1P2RY12PDE5A | |
| SCHEMBL7008986 | 0.88 | PDE4A (0.55) | P2RY12PDE5AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7020325 | 0.88 | HRH4 (0.47) | PDE5AHRH4HTR3AHTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |