Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.47 |
| ▸ | PDE5A | O76074 | 2/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 12/20 | 0.45 |
| ▸ | TCF7L2 | Q9NQB0 | 12/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017442 | 0.93 | CTNNB1 (0.49) | HRH4CTNNB1TCF7L2 | |
| SCHEMBL7017246 | 0.91 | HRH4 (0.44) | HRH4PDE5ACTNNB1TCF7L2HTR3A | |
| SCHEMBL7014497 | 0.89 | ICAM1 (0.48) | HRH4PDE5ACTNNB1TCF7L2HTR3A | |
| SCHEMBL7020325 | 0.89 | HRH4 (0.47) | HRH4PDE5ACTNNB1TCF7L2HTR3A | |
| SCHEMBL7011197 | 0.89 | PDE4A (0.43) | HRH4PDE5ACTNNB1TCF7L2HTR3A | |
| SCHEMBL7020117 | 0.89 | PDE5A (0.42) | HRH4PDE5ADRD3KDM4EMAPT | |
| SCHEMBL7014271 | 0.88 | APP (0.42) | HRH4PDE5A | |
| SCHEMBL8182382 | 0.88 | CTNNB1 (0.51) | HRH4PDE5ACTNNB1TCF7L2HTR3A | |
| SCHEMBL7019976 | 0.87 | PDE5A (0.43) | HRH4PDE5ACTNNB1TCF7L2HTR3A | |
| SCHEMBL7019721 | 0.87 | PDE4A (0.50) | PDE5ACTNNB1TCF7L2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |