Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022190 | 1.00 | ADORA3 (0.41) | ADORA3ADORA2AADORA1ADRA1BPARP1 | |
| SCHEMBL7022004 | 0.88 | ADRA1B (0.42) | ADORA3ADORA2AADORA1ADRA1BPARP1 | |
| SCHEMBL7022008 | 0.88 | ADRA1B (0.42) | ADORA3ADORA2AADORA1ADRA1BPARP1 | |
| SCHEMBL7018089 | 0.81 | KDM4E (0.43) | ADORA3ADORA2AADRA1BKDM4E | |
| SCHEMBL7018087 | 0.81 | KDM4E (0.43) | ADORA3ADORA2AADRA1BKDM4E | |
| SCHEMBL7015733 | 0.80 | FEN1 (0.50) | ADRA1BCYP1A2KMT2AKDM4EALDH1A1 | |
| SCHEMBL7015737 | 0.80 | FEN1 (0.50) | ADRA1BCYP1A2KMT2AKDM4EALDH1A1 | |
| SCHEMBL7017374 | 0.79 | CYP1A2 (0.60) | ADORA3ADORA2AADORA1CYP1A2MEN1 | |
| SCHEMBL27789064 | 0.77 | ADRA1B (0.40) | ADORA3ADORA2AADORA1ADRA1BPARP1 | |
| SCHEMBL30970867 | 0.76 | ADORA3 (0.62) | ADORA3ADORA2AADORA1ADRA1BPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | claimed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | claimed |
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | disclosed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |