Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 15/20 | 0.81 |
| ▸ | ADRB3 | P13945 | 15/20 | 0.81 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014595 | 1.00 | ADRB1 (0.81) | ADRB1ADRB3ADRB2MEN1KMT2A | |
| SCHEMBL9655116 | 0.95 | ADRB1 (0.74) | ADRB1ADRB3ADRB2MEN1KMT2A | |
| SCHEMBL7013581 | 0.93 | ADRB1 (0.71) | ADRB1ADRB3ADRB2MEN1KMT2A | |
| SCHEMBL15451481 | 0.88 | ADRB3 (0.66) | ADRB1ADRB3ADRB2MEN1KMT2A | |
| SCHEMBL5964090 | 0.86 | ADRB1 (0.62) | ADRB1ADRB3ADRB2MEN1KMT2A | |
| SCHEMBL11230720 | 0.85 | ADRB1 (0.67) | ADRB1ADRB3ADRB2MEN1KMT2A | |
| SCHEMBL27478454 | 0.85 | ADRB1 (0.78) | ADRB1ADRB3ADRB2MEN1KMT2A | |
| SCHEMBL5964618 | 0.84 | ADRB3 (0.61) | ADRB1ADRB3ADRB2KMT2AALDH1A1 | |
| SCHEMBL9817936 | 0.84 | ADRB1 (0.73) | ADRB1ADRB3ADRB2 | |
| SCHEMBL4204100 | 0.83 | KCNH2 (0.66) | ADRB1ADRB3ADRB2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972769-B1 | NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMA CO LTD (JP) | 2003-04-16 | — | — | EP | disclosed |
| US-6177454-B1 | ANTIDIABETIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| US-6048884-A | ANTIDIABETIC AGENTS; HYPOGLYCEMIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-04-11 | — | — | US | disclosed |
| EP-0972769-A1 | NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-01-19 | — | — | EP | disclosed |