Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017615 | 0.95 | PDE5A (0.46) | PDE5A | |
| SCHEMBL7016681 | 0.92 | KDM4E (0.40) | PDE5AKMT2ATP53PDE2APDE3B | |
| SCHEMBL7019915 | 0.92 | PDE5A (0.42) | PDE5ATP53CCR4TSHR | |
| SCHEMBL7018206 | 0.90 | KMT2A (0.40) | PDE5AKMT2APDE2ATSHR | |
| SCHEMBL8186510 | 0.89 | ALDH1A1 (0.48) | PDE5AKMT2ATP53MEN1POLB | |
| SCHEMBL7017441 | 0.89 | PDE5A (0.46) | PDE5A | |
| SCHEMBL7013874 | 0.88 | KDM4E (0.43) | KMT2ATHRB | |
| SCHEMBL7008973 | 0.88 | KMT2A (0.42) | PDE5AKMT2AMEN1 | |
| SCHEMBL7422776 | 0.87 | CCR4 (0.42) | PDE5ATP53CCR4 | |
| SCHEMBL7018507 | 0.87 | PDE5A (0.48) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |