Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.52 |
| ▸ | GCK | P35557 | 4/20 | 0.34 |
| ▸ | POLQ | O75417 | 2/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020123 | 0.95 | PDE4D (0.51) | PDE4APDE4BPDE4CPDE4DGCK | |
| SCHEMBL7017103 | 0.86 | PDE4D (0.53) | PDE4APDE4BPDE4CPDE4DGCK | |
| SCHEMBL7019218 | 0.79 | PDE4B (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7019051 | 0.78 | PDE4B (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7017332 | 0.75 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7019382 | 0.75 | PDE4B (0.40) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7017625 | 0.74 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7014973 | 0.72 | PDE4D (0.65) | PDE4APDE4BPDE4CPDE4DGCK | |
| SCHEMBL7015621 | 0.71 | PDE4D (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7015704 | 0.70 | PDE4D (0.59) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | claimed |