Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27399131 | 0.81 | RPS6KA3 (0.46) | RPS6KA3KMT2ADGAT1CYP19A1MAP4K4 | |
| SCHEMBL7013819 | 0.77 | DGAT1 (0.41) | RPS6KA3KMT2ADGAT1SLC9A1NPSR1 | |
| SCHEMBL7006231 | 0.77 | DGAT1 (0.67) | KMT2ADGAT1SLC9A1MAP4K4NPSR1 | |
| SCHEMBL15723948 | 0.74 | CYP17A1 (0.39) | RPS6KA3KMT2ADGAT1SLC9A1CYP19A1 | |
| SCHEMBL7006695 | 0.73 | ERBB2 (0.47) | RPS6KA3DGAT1SLC9A1NPSR1CYP1A2 | |
| SCHEMBL31452803 | 0.73 | MAPK9 (0.51) | KMT2ACYP1A2CYP3A4CYP2C19KDM4E | |
| SCHEMBL4058284 | 0.71 | MEN1 (0.41) | KMT2ACOMTNPSR1KDM4EALDH1A1 | |
| SCHEMBL30046665 | 0.69 | DGAT1 (0.56) | KMT2ADGAT1MAP4K4NPSR1CYP1A2 | |
| SCHEMBL16806007 | 0.68 | GRM5 (0.39) | KMT2ACYP19A1NPSR1KDM4EALDH1A1 | |
| SCHEMBL28214521 | 0.68 | EGFR (0.39) | KMT2ACOMTMAP4K4CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |