Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | APP | P05067 | 4/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020191 | 0.93 | PDE5A (0.48) | PDE5A | |
| SCHEMBL7019915 | 0.93 | PDE5A (0.42) | TP53PDE5AAPPCCR4 | |
| SCHEMBL7016681 | 0.91 | KDM4E (0.40) | TP53GAARXFP1PDE5ANPC1 | |
| SCHEMBL8179618 | 0.90 | PDE4A (0.44) | TP53GAARXFP1PDE5ANPC1 | |
| SCHEMBL7020121 | 0.88 | GAA (0.41) | GAARXFP1PDE5AALDH1A1KDM4E | |
| SCHEMBL7012724 | 0.88 | GAA (0.45) | GAARXFP1ALDH1A1KDM4ELMNA | |
| SCHEMBL7012162 | 0.87 | ALDH1A1 (0.44) | GAARXFP1PDE5ARAB9AEPHX2 | |
| SCHEMBL7018507 | 0.87 | PDE5A (0.48) | PDE5A | |
| SCHEMBL7022471 | 0.87 | TP53 (0.41) | TP53PDE5ASMN1; SMN2ACHEAPP | |
| SCHEMBL7013924 | 0.87 | MAPT (0.45) | TP53GAAALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |