Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 3/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 5/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015450 | 0.93 | PDE5A (0.48) | PDE5A | |
| SCHEMBL7016510 | 0.91 | TP53 (0.40) | TP53PDE5AESR1CCR4APP | |
| SCHEMBL8183548 | 0.90 | PDE4A (0.44) | TP53PDE5AESR1CCR4APP | |
| SCHEMBL7018352 | 0.88 | ESR1 (0.44) | PDE5AESR1 | |
| SCHEMBL7013793 | 0.88 | CTNNB1 (0.45) | ESR1 | |
| SCHEMBL7018707 | 0.87 | ESR1 (0.44) | PDE5AESR1NPSR1 | |
| SCHEMBL7015293 | 0.87 | TP53 (0.41) | TP53PDE5ACCR4APPACHE | |
| SCHEMBL8180303 | 0.86 | ALDH1A1 (0.49) | TP53PDE5AESR1SMN1; SMN2 | |
| SCHEMBL7019915 | 0.86 | PDE5A (0.42) | TP53PDE5ACCR4APP | |
| SCHEMBL7014926 | 0.86 | PDE4A (0.46) | TP53PDE5AESR1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |