Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.42 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022838 | 0.92 | PDE4B (0.47) | PDE4APDE4BPDE4CPDE4DROCK2 | |
| SCHEMBL7019627 | 0.83 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DROCK2 | |
| SCHEMBL7018124 | 0.80 | RPS6KA3 (0.42) | ROCK2PDCD1CD274AVPR1AAVPR1B | |
| SCHEMBL7023914 | 0.80 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DROCK2 | |
| SCHEMBL7019784 | 0.79 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DROCK2 | |
| SCHEMBL7021672 | 0.78 | BRD4 (0.59) | PDE4APDE4BPDE4CPDE4DROCK2 | |
| SCHEMBL7024013 | 0.77 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DAVPR1A | |
| SCHEMBL7019311 | 0.76 | ROCK2 (0.46) | PDE4APDE4BPDE4CPDE4DROCK2 | |
| SCHEMBL7019383 | 0.76 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DROCK2 | |
| SCHEMBL7017182 | 0.75 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051415-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-09-24 | — | — | EP | disclosed |
| US-6495542-B1 | SUCH AS 2-METHOXY-N-(2-METHYL-1H-BENZIMIDAZOL-4-YL)-4-(2,3,4,5-TETRAHYDRO-5-OXO-1H-1-BENZAZEPIN-1-YL)CARBONYL-BENZAM IDE; HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-17 | — | — | US | disclosed |
| EP-1051415-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037637-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-07-29 | — | — | WO | disclosed |