Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012838 | 0.84 | NPC1 (0.43) | ALDH1A1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL28539594 | 0.84 | KDM4E (0.63) | ALDH1A1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL1401560 | 0.82 | TSHR (0.57) | ALDH1A1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL22579325 | 0.80 | ALDH1A1 (0.47) | ALDH1A1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL17479435 | 0.80 | PTPN1 (0.45) | ALDH1A1KDM4EHSD17B10KMT2APOLB | |
| SCHEMBL12694512 | 0.80 | MAPT (0.46) | ALDH1A1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL31438543 | 0.80 | PTPN1 (0.45) | ALDH1A1KDM4EHSD17B10KMT2APOLB | |
| SCHEMBL3563696 | 0.79 | CES2 (0.55) | ALDH1A1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL4968519 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL2134625 | 0.79 | KDM4E (0.52) | ALDH1A1KDM4EHSD17B10KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |