Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015510 | 1.00 | ADORA2B (0.39) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7017710 | 0.88 | ADORA2B (0.40) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7017712 | 0.88 | ADORA2B (0.40) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7020396 | 0.78 | GAA (0.44) | ERCC5FEN1GAA | |
| SCHEMBL7020394 | 0.78 | GAA (0.44) | ERCC5FEN1GAA | |
| SCHEMBL6516737 | 0.78 | ADORA2B (0.44) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7017646 | 0.75 | ERCC1 (0.53) | ERCC1FEN1ERCC4HDAC1 | |
| SCHEMBL7017005 | 0.75 | ADORA2B (0.38) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7017008 | 0.75 | ADORA2B (0.38) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7101330 | 0.74 | ADORA2B (0.40) | ADORA2BERCC1ERCC5FEN1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |