Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | PARG | Q86W56 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6522410 | 0.81 | ALDH1A1 (0.50) | ADORA2BADORA2APDE4BPDE4APDE4C | |
| SCHEMBL6514929 | 0.80 | ADORA2B (0.40) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL6513423 | 0.80 | ERCC1 (0.63) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7015507 | 0.78 | ADORA2B (0.39) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7015510 | 0.78 | ADORA2B (0.39) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7017008 | 0.77 | ADORA2B (0.38) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7017712 | 0.77 | ADORA2B (0.40) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7017710 | 0.77 | ADORA2B (0.40) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7017005 | 0.77 | ADORA2B (0.38) | ADORA2BERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL7101330 | 0.76 | ADORA2B (0.40) | ADORA2BERCC1ERCC5FEN1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004126-A1 | Method of determining potential allosterically-binding matrix metalloproteinase inhibitors | ANDRIANJARA CHARLES (FR) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004126-A1 | Method of determining potential allosterically-binding matrix metalloproteinase inhibitors | MMP13, MMP12, MMP25 | ADORA2B 3585/4885ADORA2A 2900/4885PDE4B 3058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.