Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | CPA1 | P15085 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CTH | P32929 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL923346 | 0.79 | KMT2A (0.39) | ALDH1A1TDP1MAPTLMNAMEN1 | |
| SCHEMBL12887950 | 0.79 | MEN1 (0.39) | ALDH1A1TDP1MAPTLMNAMEN1 | |
| SCHEMBL7211193 | 0.78 | GAA (0.46) | EGLN1ALDH1A1MAPTTET2KDM4E | |
| SCHEMBL28478472 | 0.77 | MEN1 (0.36) | EGLN1ALDH1A1TDP1MAPTLMNA | |
| SCHEMBL1852852 | 0.77 | EGLN1 (0.40) | EGLN1ALDH1A1TDP1MAPTLMNA | |
| SCHEMBL6399291 | 0.76 | CYP2D6 (0.54) | EGLN1ALDH1A1TDP1MAPTLMNA | |
| SCHEMBL16689827 | 0.76 | MEN1 (0.37) | ALDH1A1TDP1MAPTMEN1KMT2A | |
| SCHEMBL19384149 | 0.75 | KMT2A (0.39) | EGLN1ALDH1A1TDP1MAPTLMNA | |
| SCHEMBL9999987 | 0.75 | EGLN1 (0.62) | EGLN1ALDH1A1TDP1MAPTLMNA | |
| SCHEMBL136474 | 0.73 | ALDH1A1 (0.39) | ALDH1A1TDP1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341784-A2 | PROCESS FOR MAKING A THROMBIN INHIBITOR | Merck & Co., Inc. (US) | 2003-09-10 | — | — | EP | disclosed |
| EP-1267876-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2002046160-A2 | PROCESS FOR MAKING A THROMBIN INHIBITOR | MERCK & CO., INC. (US) | 2002-06-13 | — | — | WO | disclosed |
| WO-2001092234-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-12-06 | — | — | WO | disclosed |
| WO-2001070229-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-09-27 | — | — | WO | disclosed |