Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.41 |
| ▸ | PDE1A | P54750 | 4/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261819 | 0.94 | PDE5A (0.40) | PDE5AALDH1A1KDM4EHSD17B10ADORA2A | |
| SCHEMBL5263574 | 0.91 | PDE5A (0.41) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL5260943 | 0.87 | PDE5A (0.41) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL5261815 | 0.82 | PDE5A (0.40) | PDE5AADORA2AADORA2BADORA1 | |
| SCHEMBL5262492 | 0.81 | PDE5A (0.57) | PDE5APDE1APDE1BPDE1CADORA2A | |
| SCHEMBL5261432 | 0.81 | PDE5A (0.49) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL5830709 | 0.81 | PDE5A (0.51) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL5258961 | 0.81 | PDE5A (0.38) | PDE5APDE1AKDM4E | |
| SCHEMBL5831211 | 0.80 | PDE5A (0.51) | PDE5APDE1APDE1BPDE1CADORA1 | |
| SCHEMBL5263571 | 0.79 | PDE5A (0.41) | PDE5APDE1APDE1BPDE1CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307458-A1 | PYRROLOTRIAZOLOPYRIMIDINONE DERIVATIVES | Almirall Prodesfarma, S.A. (ES) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012246-A1 | PYRROLOTRIAZOLOPYRIMIDINONE DERIVATIVES | ALMIRALL PRODESFARMA S.A. (ES) | 2002-02-14 | — | — | WO | disclosed |