SCHEMBL7016232

SCHEMBL7016232

Clc1ccc(Cl)n2nc(SCc3ccccc3)nc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.46
RAB9A P51151 6/20 0.44
NPC1 O15118 4/20 0.44
ALDH1A1 P00352 1/20 0.44
KDM1A O60341 3/20 0.43
METAP2 P50579 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.42
CTSB P07858 1/20 0.41
TOP2A P11388 1/20 0.41
CKS1B P61024 1/20 0.41
SKP2 Q13309 1/20 0.41
ALOX15 P16050 2/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7019011 0.86 CKS1B (0.45) HSD17B10RAB9ANPC1ALDH1A1KDM1A
SCHEMBL7014524 0.86 RAB9A (0.47) HSD17B10RAB9ANPC1ALDH1A1KDM1A
SCHEMBL7841559 0.83 ALDH1A1 (0.57) HSD17B10RAB9ANPC1ALDH1A1KDM1A
SCHEMBL7849961 0.83 ALDH1A1 (0.51) HSD17B10RAB9ANPC1ALDH1A1KDM1A
SCHEMBL7840525 0.81 KDM1A (0.48) HSD17B10RAB9ANPC1ALDH1A1KDM1A
SCHEMBL7851723 0.78 HSD17B10 (0.47) HSD17B10RAB9ANPC1ALDH1A1KDM1A
SCHEMBL7016465 0.77 RAB9A (0.57) HSD17B10RAB9ANPC1ALDH1A1METAP2
SCHEMBL8111887 0.76 ALDH1A1 (0.49) HSD17B10RAB9ANPC1ALDH1A1KDM1A
SCHEMBL9641712 0.75 RAB9A (0.43) HSD17B10RAB9ANPC1ALDH1A1KDM1A
SCHEMBL8803109 0.74 KDM1A (0.42) HSD17B10RAB9ANPC1ALDH1A1KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0972774-B1 2-Benzylthio-8-amino(1,2,4)triazolo(1,5-a)pyridines DOW AGROSCIENCES LLC (US) 2003-02-26 EP disclosed
EP-0717743-B1 N-ARYL 1,2,4]TRIAZOLO 1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES DOW AGROSCIENCES LLC (US) 2001-11-14 EP disclosed
EP-0972774-A2 2-Benzylthio-8-amino(1,2,4)triazolo(1,5-pyridines Dow AgroSciences LLC (US) 2000-01-19 EP disclosed
EP-0789698-B1 N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES DOW AGROSCIENCES LLC (US) 1999-07-07 EP disclosed
EP-0789698-A1 N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES DOWELANCO (US) 1997-08-20 EP disclosed
WO-1997008172-A1 N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES DOWELANCO (US) 1997-03-06 WO disclosed
US-5571775-A EFFECTIVE ON A BROAD SPECTRUM OF VEGETATION AT LOW APPLICATION RATES DOWELANCO (US) 1996-11-05 US disclosed
EP-0717743-A1 N-ARYL 1,2,4]TRIAZOLO 1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES DOWELANCO (US) 1996-06-26 EP disclosed
WO-1996001826-A1 N-ARYL[1,2,4]TRIAZOLO[1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES DOWELANCO (US) 1996-01-25 WO disclosed