Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429441 | 0.87 | AGTR1 (0.48) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL7433404 | 0.86 | AGTR1 (0.49) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL7428309 | 0.85 | AGTR1 (0.44) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL7435529 | 0.85 | AGTR1 (0.44) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL683804 | 0.77 | AGTR1 (0.66) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL683885 | 0.77 | AGTR1 (0.65) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL5767794 | 0.76 | CA12 (0.58) | — | |
| SCHEMBL13714544 | 0.75 | AGTR1 (0.68) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL3187321 | 0.73 | AGTR1 (0.54) | AGTR1TBXA2RAGTR2PDE3A | |
| Tasosartan SCHEMBL49627 | 0.73 | AGTR1 (1.00) | AGTR1TBXA2RAGTR2PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846117-B1 | PROCESS FOR PREPARATION OF BIPHENYL DERIVATIVES | WYETH CORP (US) | 2003-05-14 | — | — | EP | claimed |
| EP-0846117-A1 | PROCESS FOR PREPARATION OF BIPHENYL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-06-10 | — | — | EP | claimed |
| WO-1996040684-A1 | PROCESS FOR PREPARATION OF BIPHENYL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-19 | — | — | WO | claimed |
| EP-0846117-B1 | PROCESS FOR PREPARATION OF BIPHENYL DERIVATIVES | WYETH CORP (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-0994881-B1 | ORTHO-METALATION PROCESS FOR THE SYNTHESIS OF 2-SUBSTITUTED-1-(TETRAZOL-5-YL)BENZENES | ZAMBON SPA (IT) | 2002-09-18 | — | — | EP | disclosed |
| US-6271375-B1 | ESPECIALLY PREPARATION OF TASOSARTAN; GRIGNARD REAGENTS | ZAMBON GROUP S.P.A. (IT) | 2001-08-07 | — | — | US | disclosed |
| EP-0994881-A1 | ORTHO-METALATION PROCESS FOR THE SYNTHESIS OF 2-SUBSTITUTED-1-(TETRAZOL-5-YL)BENZENES | ZAMBON GROUP S.p.A. (IT) | 2000-04-26 | — | — | EP | disclosed |
| US-5977372-A | Chloro or bromo[2-[2-(tert-butyl)-2H-tetrazol-5-yl]phenyl]zinc intermediates | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999001459-A1 | ORTHO-METALATION PROCESS FOR THE SYNTHESIS OF 2-SUBSTITUTED-1-(TETRAZOL-5-YL)BENZENES | ZAMBON GROUP S.P.A. (IT) | 1999-01-14 | — | — | WO | disclosed |
| EP-0618207-B1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PROD (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0863143-A1 | Intermediates useful in the production of pyridopyrimidone angiotensin AII antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5760220-A | REACTING PROTECTED TETRAZOLYLPHENYL ZINC HALIDE WITH HALOPHENYLMETHYL PYRIDO/2,3-D/PYRIMIDONE IN PRESENCE OF PALLADIUM OR NICKEL CATALYST | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0539086-B1 | Condensed pyrimidine derivatives and their use as angiotensine II antagonists | AMERICAN HOME PROD (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1996040684-A1 | PROCESS FOR PREPARATION OF BIPHENYL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5498776-A | Substituted pyrrolopyrimidines and pyridopyrimidines useful as angiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-03-12 | — | — | US | disclosed |
| US-5466692-A | Substituted pyridopyrimidines and antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0618207-A1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5256654-A | Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-26 | — | — | US | disclosed |
| EP-0539086-A2 | Condensed pyrimidine derivatives and their use as angiotensine II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5149699-A | Substituted pyridopyrimidines useful as antgiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |