Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016278 | 0.85 | AGTR1 (0.57) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL7433404 | 0.82 | AGTR1 (0.49) | AGTR1TBXA2RAGTR2PDE3AHDAC1 | |
| SCHEMBL7429441 | 0.75 | AGTR1 (0.48) | AGTR1TBXA2RAGTR2PDE3AHDAC1 | |
| SCHEMBL7435529 | 0.74 | AGTR1 (0.44) | AGTR1TBXA2RAGTR2PDE3ALMNA | |
| SCHEMBL5767794 | 0.72 | CA12 (0.58) | LMNAHTTHDAC1HDAC8HDAC6 | |
| SCHEMBL11105334 | 0.67 | MEN1 (0.50) | LMNAHTTHDAC1HDAC8HDAC6 | |
| SCHEMBL683804 | 0.65 | AGTR1 (0.66) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL19002513 | 0.63 | ALDH1A1 (0.66) | LMNAHDAC6ALDH1A1 | |
| SCHEMBL22980462 | 0.60 | CA1 (0.60) | LMNAHTTHDAC1HDAC8HDAC6 | |
| SCHEMBL22738852 | 0.59 | MEN1 (0.41) | LMNAHTTHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618207-B1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PROD (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0863143-A1 | Intermediates useful in the production of pyridopyrimidone angiotensin AII antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5466692-A | Substituted pyridopyrimidines and antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0618207-A1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-10-05 | — | — | EP | disclosed |