Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | IL2 | P60568 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019188 | 0.85 | KDM4E (0.35) | KDM4EBRD4CREBBPHRH3 | |
| SCHEMBL8931822 | 0.76 | KDM4E (0.41) | KDM4EATMHTTALDH1A1LMNA | |
| SCHEMBL8486524 | 0.73 | KDM4E (0.46) | KDM4EATMHTTALDH1A1LMNA | |
| SCHEMBL7016208 | 0.71 | NR3C1 (0.46) | KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL29616919 | 0.71 | KDM4E (0.61) | KDM4EATMHTTALDH1A1LMNA | |
| SCHEMBL18380643 | 0.71 | KDM4E (0.61) | KDM4EATMHTTALDH1A1LMNA | |
| SCHEMBL10835648 | 0.71 | KDM4E (0.50) | KDM4EATMHTTALDH1A1LMNA | |
| SCHEMBL7015242 | 0.71 | NPC1 (0.44) | KDM4EBRD4HRH3 | |
| SCHEMBL7112634 | 0.70 | KDM4E (0.53) | KDM4EATMHTTALDH1A1LMNA | |
| SCHEMBL371 | 0.70 | KDM4E (0.49) | KDM4EATMHTTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574174-B1 | Angiotensin II antagonists | LILLY CO ELI (US) | 2003-08-13 | — | — | EP | disclosed |
| US-5612360-A | AROMATIC N-HETEROCYCLIC COMPOUNDS AS HYPOTENSIVE AGENTS WITH ACID GROUPS, SULFONYLCARBOXAMIDES OR TETRAZOLE GROUPS | ELI LILLY AND COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| US-5569768-A | USEFUL IN TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, GLAUCOMA AND RENAL INSUFFICIENCY | ELI LILLY AND COMPANY (US) | 1996-10-29 | — | — | US | disclosed |
| US-5556981-A | Angiotensin II antagonist intermediates | ELI LILLY AND COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| EP-0574174-A2 | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1993-12-15 | — | — | EP | disclosed |