Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 14/20 | 0.42 |
| ▸ | TCF7L2 | Q9NQB0 | 14/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012148 | 0.94 | CTNNB1 (0.48) | HRH4CTNNB1TCF7L2 | |
| SCHEMBL7018883 | 0.91 | CTNNB1 (0.42) | PDE5AHRH4CTNNB1TCF7L2HTR3A | |
| SCHEMBL7019018 | 0.89 | CTNNB1 (0.42) | PDE5AHRH4CTNNB1TCF7L2 | |
| SCHEMBL7013401 | 0.89 | MET (0.40) | PDE5A | |
| SCHEMBL8184409 | 0.89 | PDE4A (0.47) | PDE5AHRH4HTR2ADRD3CTNNB1 | |
| SCHEMBL7016859 | 0.88 | ACHE (0.40) | PDE5ACTNNB1TCF7L2 | |
| SCHEMBL7011893 | 0.87 | PDE4A (0.54) | PDE5ACTNNB1TCF7L2KDM4EMAPT | |
| SCHEMBL7015105 | 0.87 | PDE4A (0.48) | PDE5ACTNNB1TCF7L2KDM4E | |
| SCHEMBL7014497 | 0.87 | ICAM1 (0.48) | PDE5AHRH4HTR2ADRD3CTNNB1 | |
| SCHEMBL7016359 | 0.87 | HRH4 (0.47) | PDE5AHRH4HTR2ADRD3CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |