Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 8/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010020 | 0.90 | SIGMAR1 (0.46) | SIGMAR1TMEM97ADRA1DSLC6A3 | |
| SCHEMBL7016352 | 0.89 | SIGMAR1 (0.45) | NR1H2NR1H3PDK1PDK2PDK3 | |
| SCHEMBL7020197 | 0.86 | SIGMAR1 (0.42) | NR1H2NR1H3SIGMAR1TMEM97HDAC1 | |
| SCHEMBL7013241 | 0.86 | SIGMAR1 (0.42) | NR1H2NR1H3SIGMAR1TMEM97HDAC1 | |
| SCHEMBL7016082 | 0.80 | NPSR1 (0.46) | NR1H2NR1H3SIGMAR1TMEM97TP53 | |
| SCHEMBL21590367 | 0.76 | NR1H2 (0.51) | NR1H2NR1H3PDK1PDK2PDK3 | |
| SCHEMBL21594457 | 0.76 | NR1H2 (0.51) | NR1H2NR1H3PDK1PDK2PDK3 | |
| SCHEMBL7010091 | 0.76 | NR1H2 (0.41) | NR1H2NR1H3 | |
| SCHEMBL30554118 | 0.74 | PARP1 (0.45) | NR1H2NR1H3PDK1PDK2PDK3 | |
| SCHEMBL30554121 | 0.74 | PARP1 (0.45) | NR1H2NR1H3PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030187023-A1 | Sulfone derivatives, process for their production and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-10-02 | — | — | US | disclosed |
| EP-1302462-A1 | SULFONE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2003-04-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187023-A1 | Sulfone derivatives, process for their production and use thereof | SULT1E1, RRS1, SHH | NR1H2 330/4885NR1H3 534/4885PDK1 4505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.