Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 14/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | HRH2 | P25021 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016352 | 0.92 | SIGMAR1 (0.45) | SIGMAR1TMEM97HRH2HRH1HTR1A | |
| SCHEMBL7016513 | 0.90 | NR1H2 (0.48) | SIGMAR1TMEM97ADRA1DSLC6A3 | |
| SCHEMBL7013241 | 0.90 | SIGMAR1 (0.42) | SIGMAR1TMEM97HRH2HRH1HTR1A | |
| SCHEMBL7020197 | 0.88 | SIGMAR1 (0.42) | SIGMAR1TMEM97HRH2HRH1HTR1A | |
| SCHEMBL7016082 | 0.82 | NPSR1 (0.46) | SIGMAR1TMEM97ADRA1DSLC6A3 | |
| SCHEMBL7015153 | 0.78 | MAPT (0.42) | — | |
| SCHEMBL21590367 | 0.78 | NR1H2 (0.51) | SIGMAR1TMEM97HRH2HRH1HTR1A | |
| SCHEMBL21594457 | 0.78 | NR1H2 (0.51) | SIGMAR1TMEM97HRH2HRH1HTR1A | |
| SCHEMBL29973124 | 0.73 | CHRM4 (0.54) | TMEM97 | |
| SCHEMBL7013012 | 0.73 | AOC3 (0.39) | SIGMAR1TMEM97HRH2HRH1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030187023-A1 | Sulfone derivatives, process for their production and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-10-02 | — | — | US | disclosed |
| EP-1302462-A1 | SULFONE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2003-04-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187023-A1 | Sulfone derivatives, process for their production and use thereof | SULT1E1, RRS1, SHH | SIGMAR1 270/4885TMEM97 3732/4885SLC6A2 4258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.