Iodide

Iodide

SCHEMBL7016592

I.c1ccc2c(c1)CCN1CCCC21

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG

The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 3/20 0.96
TAAR1 Q96RJ0 1/20 0.57
OPRM1 P35372 1/20 0.50
OPRK1 P41145 1/20 0.50
OPRL1 P41146 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2811534 0.98 CHRNA7 (1.00) CHRNA7TAAR1OPRM1OPRK1OPRL1
Hydrochloric Acid SCHEMBL7509300 0.96 CHRNA7 (0.96) CHRNA7TAAR1OPRM1OPRK1OPRL1
SCHEMBL3475010 0.93 CHRNA7 (0.90) CHRNA7TAAR1OPRM1OPRK1OPRL1
Iodide SCHEMBL7847003 0.93 CHRNA7 (0.83) CHRNA7TAAR1OPRM1OPRK1OPRL1
SCHEMBL14239889 0.93 CHRNA7 (0.90) CHRNA7TAAR1OPRM1OPRK1OPRL1
Hydrochloric Acid SCHEMBL7516224 0.91 CHRNA7 (0.87) CHRNA7TAAR1OPRM1OPRK1OPRL1
SCHEMBL10753534 0.89 CHRNA7 (0.82) CHRNA7TAAR1OPRM1OPRK1OPRL1
SCHEMBL20137193 0.87 CHRNA7 (0.80) CHRNA7TAAR1OPRM1OPRK1OPRL1
SCHEMBL5899579 0.87 CHRNA7 (0.80) CHRNA7TAAR1OPRM1OPRK1OPRL1
Nitric Acid SCHEMBL7839376 0.86 CHRNA7 (0.77) CHRNA7TAAR1OPRM1OPRK1OPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1102769-B1 TRICYCLIC CARBOXAMIDES SMITHKLINE BEECHAM PLC (GB) 2003-04-16 EP disclosed
EP-1102769-A2 TRICYCLIC CARBOXAMIDES SMITHKLINE BEECHAM PLC (GB) 2001-05-30 EP disclosed
WO-2000008020-A2 TRICYCLIC CARBOXAMIDES SMITHKLINE BEECHAM P.L.C. (GB) 2000-02-17 WO disclosed
WO-2000008023-A1 CONDENSED TRICYCLIC PIPERIDINES HAVING ANTI-CONVULSANT ACTIVITY SMITHKLINE BEECHAM PLC (GB) 2000-02-17 WO disclosed