Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 1.00 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7509300 | 0.98 | CHRNA7 (0.96) | CHRNA7TAAR1OPRM1OPRK1OPRL1 | |
| Iodide SCHEMBL7016592 | 0.98 | CHRNA7 (0.96) | CHRNA7TAAR1OPRM1OPRK1OPRL1 | |
| SCHEMBL3475010 | 0.95 | CHRNA7 (0.90) | CHRNA7TAAR1OPRM1OPRK1OPRL1 | |
| SCHEMBL14239889 | 0.95 | CHRNA7 (0.90) | CHRNA7TAAR1OPRM1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL7516224 | 0.93 | CHRNA7 (0.87) | CHRNA7TAAR1OPRM1OPRK1OPRL1 | |
| Iodide SCHEMBL7847003 | 0.91 | CHRNA7 (0.83) | CHRNA7TAAR1OPRM1OPRK1OPRL1 | |
| SCHEMBL10753534 | 0.90 | CHRNA7 (0.82) | CHRNA7TAAR1OPRM1OPRK1OPRL1 | |
| SCHEMBL20137193 | 0.89 | CHRNA7 (0.80) | CHRNA7TAAR1OPRM1OPRK1OPRL1 | |
| SCHEMBL5899579 | 0.89 | CHRNA7 (0.80) | CHRNA7TAAR1OPRM1OPRK1OPRL1 | |
| Nitric Acid SCHEMBL7839376 | 0.88 | CHRNA7 (0.77) | CHRNA7TAAR1OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120321559-A1 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS | APODACA RICHARD (US) | 2012-12-20 | — | — | US | disclosed |
| US-8273762-B2 | Hexahydro-pyrrolo-isoquinoline compounds | JANSSEN PHARMACEUTICA NV (BE) | 2012-09-25 | — | — | US | disclosed |
| US-20100240648-A1 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-23 | — | — | US | disclosed |
| US-7754882-B2 | Hexahydro-pyrrolo-isoquinoline compounds | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-13 | — | — | US | disclosed |
| US-20060293316-A1 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-28 | — | — | US | disclosed |
| EP-1212103-B1 | 4-FLUOROALKYL-3-HALOPHENYL NORTROPANES | UNIV EMORY (US) | 2004-11-03 | — | — | EP | disclosed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-20020099184-A1 | 4-Haloethenyphenyl tropane:serotonin transporter imaging agents | ENERGY, UNITED STATES DEPARTMENT OF | 2002-07-25 | — | — | US | disclosed |
| US-6399042-B1 | HALOGEN RADIOLABELED IMAGING AGENTS FOR VISUALIZING THE LOCATION AND DENSITY OF SEROTONIN TRANSPORTER BY POSITRON EMISSION TOMOGRAPHY | EMORY UNIVERSITY | 2002-06-04 | — | — | US | disclosed |
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |
| WO-2000008023-A1 | CONDENSED TRICYCLIC PIPERIDINES HAVING ANTI-CONVULSANT ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-17 | — | — | WO | disclosed |
| US-5929085-A | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 1999-07-27 | — | — | US | disclosed |
| US-5919797-A | DIAGNOSIS, THERAPY PSYCHOLOGICAL DISORDERS | EMORY UNIVERSITY (US) | 1999-07-06 | — | — | US | disclosed |
| EP-0130069-B1 | HEXAHYDROPYRROLO (2,1-A) ISOQUINOLINE DERIVATIVES | McNeilab, Inc. (US) | 1990-12-12 | — | — | EP | disclosed |
| US-4719216-A | Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants | MCNEILAB, INC. (US) | 1988-01-12 | — | — | US | disclosed |
| US-4719216-A | Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants | MCNEILAB, INC. (US) | 1988-01-12 | — | — | US | disclosed |
| US-4595688-A | Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof | MCNEILAB, INC. (US) | 1986-06-17 | — | — | US | disclosed |
| US-4595688-A | Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof | MCNEILAB, INC. (US) | 1986-06-17 | — | — | US | disclosed |
| EP-0130069-A2 | Hexahydropyrrolo (2,1-a) isoquinoline derivatives | McNeilab, Inc. (US) | 1985-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099184-A1 | 4-Haloethenyphenyl tropane:serotonin transporter imaging agents | SLC6A4, SLC6A2, SLC6A3 | CHRNA7 385/4885TAAR1 97/4885OPRM1 217/4885 |
| US-20060293316-A1 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS | HRH3, HRH1, HRH4 | CHRNA7 313/4885TAAR1 130/4885OPRM1 159/4885 |
| US-20100240648-A1 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS | HRH3, HRH1, HRH4 | CHRNA7 313/4885TAAR1 130/4885OPRM1 159/4885 |
| US-20120321559-A1 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS | HRH3, HRH1, HRH4 | CHRNA7 313/4885TAAR1 130/4885OPRM1 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.