Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015219 | 0.90 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7014555 | 0.81 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL7016598 | 0.79 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DMALT1 | |
| SCHEMBL7020449 | 0.76 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DMALT1 | |
| SCHEMBL7021594 | 0.76 | PDE4D (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7020430 | 0.75 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DHSD17B10 | |
| SCHEMBL7019218 | 0.75 | PDE4B (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7020167 | 0.74 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7018517 | 0.74 | PDE4D (0.72) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7021808 | 0.73 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | claimed |