Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 13/20 | 0.57 |
| ▸ | EDNRB | P24530 | 11/20 | 0.52 |
| ▸ | CCR9 | P51686 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293947 | 0.91 | EDNRA (0.56) | EDNRAEDNRBCCR9 | |
| SCHEMBL9156436 | 0.90 | EDNRA (0.59) | EDNRAEDNRB | |
| SCHEMBL7305595 | 0.86 | EDNRA (0.74) | EDNRAEDNRB | |
| SCHEMBL8397140 | 0.83 | EDNRA (0.62) | EDNRAEDNRB | |
| SCHEMBL7947634 | 0.82 | EDNRA (0.63) | EDNRAEDNRB | |
| SCHEMBL7332503 | 0.82 | EDNRA (0.57) | EDNRAEDNRBCCR9 | |
| SCHEMBL7006412 | 0.81 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL7948180 | 0.81 | EDNRA (0.60) | EDNRAEDNRB | |
| SCHEMBL7946205 | 0.81 | EDNRA (0.60) | EDNRAEDNRB | |
| SCHEMBL7007652 | 0.81 | EDNRA (0.60) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601386-B1 | Sulphonamides | HOFFMANN LA ROCHE (CH) | 2003-02-05 | — | — | EP | claimed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| US-5420129-A | Treatment of hypertension, ischemia, vasospasms, angina | HOFFMANN-LA ROCHE INC. (US) | 1995-05-30 | — | — | US | disclosed |