Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5164712 | 0.79 | MAPT (0.44) | MAPTHPGDHSD17B10ALOX15MEN1 | |
| SCHEMBL5168319 | 0.76 | MAPT (0.40) | MAPTHPGDHSD17B10ALOX15MEN1 | |
| SCHEMBL7010442 | 0.76 | MAPT (0.38) | MAPTHPGDHSD17B10ALOX15MEN1 | |
| SCHEMBL6279815 | 0.75 | PKM (0.49) | HPGDALDH1A1KDM4EPOLBGAA | |
| SCHEMBL6645111 | 0.69 | MAPT (0.46) | MAPTHPGDHSD17B10ALDH1A1KDM4E | |
| SCHEMBL5165825 | 0.66 | RAB9A (0.38) | HPGDHSD17B10MEN1KMT2AALDH1A1 | |
| SCHEMBL5165861 | 0.65 | ATM (0.41) | MAPTALDH1A1KDM4ENPSR1GAA | |
| SCHEMBL5166401 | 0.63 | KLK7 (0.40) | MAPTHPGDHSD17B10ALDH1A1KDM4E | |
| SCHEMBL5165831 | 0.63 | KDM4E (0.47) | MAPTHPGDHSD17B10ALDH1A1KDM4E | |
| SCHEMBL5165780 | 0.63 | PKM (0.38) | MAPTALDH1A1KDM4EADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218380-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | GRUENENTHAL GMBH (DE) | 2003-12-17 | — | — | EP | claimed |
| EP-1218380-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | GRUENENTHAL GMBH (DE) | 2003-12-17 | — | — | EP | disclosed |