Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 7/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24421824 | 0.86 | MAPT (0.87) | MAPTALDH1A1KMT2AHPGDSRD5A1 | |
| SCHEMBL22606166 | 0.84 | ALDH1A1 (0.83) | MAPTALDH1A1KMT2AHPGDAPAF1 | |
| SCHEMBL6129230 | 0.84 | ALDH1A1 (0.68) | MAPTALDH1A1KMT2AHPGDSRD5A1 | |
| SCHEMBL3749456 | 0.75 | MAPT (0.57) | MAPTALDH1A1KMT2AHPGDAPAF1 | |
| SCHEMBL9445166 | 0.75 | MAPT (0.74) | MAPTALDH1A1KMT2AHPGDAPAF1 | |
| SCHEMBL16906206 | 0.75 | MAPT (0.74) | MAPTALDH1A1KMT2AHPGDUSP2 | |
| SCHEMBL1432252 | 0.73 | MAPT (0.55) | MAPTALDH1A1KMT2AHPGDAPAF1 | |
| SCHEMBL3630511 | 0.73 | MAPT (0.55) | MAPTALDH1A1KMT2AHPGDAPAF1 | |
| SCHEMBL28790486 | 0.72 | MAPT (0.69) | MAPTALDH1A1KMT2AHPGDSRD5A1 | |
| SCHEMBL15448162 | 0.71 | MAPT (0.72) | MAPTALDH1A1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |