Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019382 | 0.90 | PDE4B (0.40) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL7019218 | 0.81 | PDE4B (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7019051 | 0.80 | PDE4B (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7020123 | 0.76 | PDE4D (0.51) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7017344 | 0.75 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7017625 | 0.74 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7015704 | 0.73 | PDE4D (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7021594 | 0.72 | PDE4D (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7020796 | 0.72 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7015621 | 0.72 | PDE4D (0.49) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | claimed |