Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30194776 | 0.82 | L3MBTL1 (0.67) | POLBALDH1A1NPSR1SMN1; SMN2TSHR | |
| SCHEMBL14667448 | 0.79 | ALDH1A1 (0.66) | POLBALDH1A1NPSR1SMN1; SMN2TSHR | |
| SCHEMBL26614454 | 0.77 | MAPK1 (0.64) | ALDH1A1NPSR1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL9210565 | 0.77 | ALDH1A1 (0.72) | ALDH1A1NPSR1SMN1; SMN2TSHRRAB9A | |
| SCHEMBL11709456 | 0.75 | MEN1 (0.50) | ALDH1A1KMT2ACYP2C19 | |
| SCHEMBL14667512 | 0.75 | POLB (0.57) | POLBALDH1A1NPSR1SMN1; SMN2TSHR | |
| SCHEMBL14804197 | 0.75 | POLB (0.57) | POLBALDH1A1NPSR1SMN1; SMN2TSHR | |
| SCHEMBL10284153 | 0.74 | ALDH1A1 (0.78) | ALDH1A1NPSR1SMN1; SMN2TSHRRAB9A | |
| SCHEMBL5538352 | 0.74 | ALDH1A1 (0.78) | ALDH1A1NPSR1SMN1; SMN2TSHRRAB9A | |
| SCHEMBL11450079 | 0.74 | POLB (0.58) | POLBALDH1A1NPSR1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705832-B1 | Serotonergic modulators | LILLY CO ELI (GB) | 2003-08-13 | — | — | EP | disclosed |
| US-5563147-A | CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0705832-A1 | Serotonergic modulators | LILLY INDUSTRIES LIMITED (GB) | 1996-04-10 | — | — | EP | disclosed |