Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.35 |
| ▸ | TUBB | P07437 | 2/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804059 | 0.90 | KMT2A (0.40) | CYP1A1CYP1A2CYP1B1KDM4EHTT | |
| SCHEMBL6804062 | 0.90 | KMT2A (0.40) | CYP1A1CYP1A2CYP1B1KDM4EHTT | |
| SCHEMBL6700295 | 0.90 | KMT2A (0.40) | CYP1A1CYP1A2CYP1B1KDM4EHTT | |
| SCHEMBL6701095 | 0.82 | ALDH1A1 (0.49) | CYP1A2KDM4EHTTLMNAL3MBTL1 | |
| SCHEMBL6804691 | 0.82 | ALDH1A1 (0.49) | CYP1A2KDM4EHTTLMNAL3MBTL1 | |
| SCHEMBL6702099 | 0.78 | CYP1A1 (0.39) | CYP1A1CYP1A2CYP1B1KDM4EHTT | |
| SCHEMBL7000926 | 0.78 | CYP1A1 (0.39) | CYP1A1CYP1A2CYP1B1KDM4EHTT | |
| SCHEMBL7015998 | 0.73 | PDE7A (0.40) | HTTL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7019520 | 0.72 | RAB9A (0.53) | CYP1A2KDM4EHTTLMNAHSD17B10 | |
| SCHEMBL7018731 | 0.70 | MAPT (0.51) | CYP1A2KDM4EHTTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | disclosed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |