Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017696 | 1.00 | ALDH1A1 (0.47) | ALDH1A1HPGDTSHRHTTL3MBTL1 | |
| SCHEMBL8347755 | 0.76 | ALDH1A1 (0.54) | ALDH1A1HPGDTSHRHTTL3MBTL1 | |
| SCHEMBL7022854 | 0.74 | CYP1A2 (0.59) | ALDH1A1HPGDTSHRNPC1RAB9A | |
| SCHEMBL12963438 | 0.74 | ALDH1A1 (0.57) | ALDH1A1HPGDTSHRHTTL3MBTL1 | |
| SCHEMBL12933337 | 0.72 | ALDH1A1 (0.50) | ALDH1A1HPGDTSHRHTTL3MBTL1 | |
| SCHEMBL7020396 | 0.71 | GAA (0.44) | L3MBTL1NPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7020394 | 0.71 | GAA (0.44) | L3MBTL1NPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7020004 | 0.71 | CYP1A2 (0.33) | MEN1KMT2A | |
| SCHEMBL7020008 | 0.71 | CYP1A2 (0.33) | MEN1KMT2A | |
| SCHEMBL7013124 | 0.70 | DAO (0.41) | ALDH1A1HPGDL3MBTL1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | claimed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | claimed |
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | disclosed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |