Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347755 | 0.83 | ALDH1A1 (0.54) | ALDH1A1HTTL3MBTL1LMNANPC1 | |
| SCHEMBL12963438 | 0.80 | ALDH1A1 (0.57) | ALDH1A1HTTL3MBTL1LMNAMAPT | |
| SCHEMBL9396723 | 0.74 | HTT (0.54) | ALDH1A1HTTL3MBTL1LMNANPC1 | |
| SCHEMBL7017696 | 0.72 | ALDH1A1 (0.47) | ALDH1A1HTTL3MBTL1LMNANPC1 | |
| SCHEMBL7017699 | 0.72 | ALDH1A1 (0.47) | ALDH1A1HTTL3MBTL1LMNANPC1 | |
| SCHEMBL11922973 | 0.72 | CYP1A2 (0.69) | ALDH1A1TSHRHPGDMEN1KMT2A | |
| SCHEMBL7653163 | 0.72 | SMN1; SMN2 (0.54) | ALDH1A1HTTL3MBTL1LMNANPC1 | |
| SCHEMBL10272767 | 0.71 | ALDH1A1 (0.57) | ALDH1A1HTTL3MBTL1LMNAMAPT | |
| SCHEMBL2801455 | 0.70 | HTT (0.54) | ALDH1A1HTTL3MBTL1LMNANPC1 | |
| SCHEMBL12505227 | 0.70 | HTT (0.50) | ALDH1A1HTTL3MBTL1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |