Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.40 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.40 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL447160 | 0.83 | ALDH1A1 (0.56) | TDP1ALDH1A1CYP3A4TSHRHPGD | |
| SCHEMBL444951 | 0.83 | LMNA (0.45) | TDP1ALDH1A1CYP3A4TSHRHPGD | |
| SCHEMBL4974489 | 0.81 | MEN1 (0.40) | TDP1ALDH1A1CYP3A4TSHRHPGD | |
| SCHEMBL22686949 | 0.73 | MAPT (0.46) | LMNAMAPTMEN1KMT2AHTT | |
| SCHEMBL3543571 | 0.71 | ALDH1A1 (0.46) | TDP1ALDH1A1CYP3A4TSHRHPGD | |
| SCHEMBL1529083 | 0.70 | ALDH1A1 (0.58) | TDP1ALDH1A1CYP3A4TSHRHPGD | |
| SCHEMBL5631287 | 0.70 | P2RX1 (0.40) | TDP1ALDH1A1CYP3A4TSHRHPGD | |
| SCHEMBL10918020 | 0.69 | ALDH1A1 (0.43) | TDP1ALDH1A1CYP3A4TSHRHPGD | |
| SCHEMBL691025 | 0.68 | TDP1 (0.59) | TDP1ALDH1A1CYP3A4TSHRHPGD | |
| SCHEMBL12706902 | 0.68 | TSHR (0.40) | TDP1ALDH1A1CYP3A4TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358161-A2 | N-PYRIDYL CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002055501-A2 | N-PYRIDYL CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMGEN INC (US) | 2002-07-18 | — | — | WO | disclosed |