Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 5/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.50 |
| ▸ | GPR4 | P46093 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018103 | 0.90 | AGTR2 (0.64) | AGTR2AGTR1GPR4 | |
| SCHEMBL7020857 | 0.88 | AGTR2 (0.49) | AGTR2AGTR1GPR4 | |
| SCHEMBL7016291 | 0.87 | AGTR1 (0.48) | AGTR2AGTR1 | |
| SCHEMBL7014060 | 0.79 | AGTR2 (0.64) | AGTR2AGTR1GPR4 | |
| SCHEMBL7011843 | 0.79 | AGTR1 (0.48) | AGTR2AGTR1 | |
| SCHEMBL7019061 | 0.77 | AGTR1 (0.65) | AGTR2AGTR1 | |
| SCHEMBL7018166 | 0.77 | AGTR1 (0.49) | AGTR2AGTR1 | |
| SCHEMBL7019312 | 0.77 | AGTR1 (0.51) | AGTR2AGTR1 | |
| SCHEMBL7010569 | 0.76 | AGTR1 (0.48) | AGTR2AGTR1 | |
| SCHEMBL7017065 | 0.76 | AGTR1 (0.66) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520423-B1 | Heterocyclic compounds, their production and use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-14 | — | — | EP | disclosed |
| US-6100252-A | SPECIFIED COMPOUNDS INCLUDING METHYL 2-BUTYL-1-((2'-(2-OXO-3H-1,2,3,5-OXATHIADIAZOL-4-YL)BIPHENYL) METHYL)-BENZIMIDAZOLE-7-CARBOXYLATE; USE TO TREAT CIRCULATORY DISEASES SUCH AS HYPERTENSIVE DISEASES AND HEART DISEASES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-08-08 | — | — | US | disclosed |
| US-5354766-A | 2-Ethoxy-1-((2'(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl) biphenyl-4-yl)methyl)benzimidazole-7-carboxylic acid; hypotensive agents; CNS activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-10-11 | — | — | US | disclosed |
| US-5243054-A | Hypotensive agents, cardiovascular disorders or nervous system disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-09-07 | — | — | US | disclosed |
| EP-0520423-A2 | Heterocyclic compounds, their production and use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-30 | — | — | EP | disclosed |