Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018361 | 0.90 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL5866812 | 0.75 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL5866999 | 0.74 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL7015575 | 0.70 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL5599986 | 0.70 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL5599789 | 0.70 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL7683348 | 0.68 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL7684228 | 0.67 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL7016669 | 0.66 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL5867048 | 0.66 | CRHR1 (0.45) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920429-B1 | SUBSTITUTED PYRIDO- OR PYRIMIDO-CONTAINING 6,6- OR 6,7-BICYCLIC DERIVATIVES | PFIZER (US) | 2003-02-19 | — | — | EP | disclosed |
| US-6492520-B1 | COMPOUNDS (I) ARE CORTICOTROPIN RELEASING FACTOR (HORMONE) CRF (CRH) ANTAGONISTS. | PFIZER INC | 2002-12-10 | — | — | US | disclosed |