Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016669 | 0.89 | CRHR1 (0.41) | CRHR1RAPGEF4 | |
| SCHEMBL27397278 | 0.81 | HTT (0.31) | — | |
| SCHEMBL7684228 | 0.80 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL7018123 | 0.76 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL7013499 | 0.73 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL5866999 | 0.68 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL7014703 | 0.68 | RAPGEF4 (0.40) | RAPGEF4 | |
| SCHEMBL7018725 | 0.68 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL3352406 | 0.67 | RAPGEF4 (0.58) | RAPGEF4 | |
| SCHEMBL5866812 | 0.67 | CRHR1 (0.45) | CRHR1RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492520-B1 | COMPOUNDS (I) ARE CORTICOTROPIN RELEASING FACTOR (HORMONE) CRF (CRH) ANTAGONISTS. | PFIZER INC | 2002-12-10 | — | — | US | disclosed |
| EP-0920429-A1 | SUBSTITUTED PYRIDO- OR PYRIMIDO-CONTAINING 6,6- OR 6,7-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998005661-A1 | SUBSTITUTED PYRIDO- OR PYRIMIDO-CONTAINING 6,6- OR 6,7-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1998-02-12 | — | — | WO | disclosed |