SCHEMBL7018753

SCHEMBL7018753

CC(CO)Oc1ccc(C(F)(F)F)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 2/20 0.45
PPARA Q07869 2/20 0.45
CYP3A4 P08684 3/20 0.44
CYP3A5 P20815 1/20 0.44
SLC6A4 P31645 5/20 0.43
SLC6A2 P23975 4/20 0.43
SLC6A3 Q01959 4/20 0.43
MEN1 O00255 4/20 0.43
KMT2A Q03164 4/20 0.43
LMNA P02545 4/20 0.43
HRH3 Q9Y5N1 2/20 0.43
NPC1 O15118 2/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C19 P33261 2/20 0.43
MTOR P42345 2/20 0.43
RAB9A P51151 2/20 0.43
KCNK2 O95069 2/20 0.43
KCNH2 Q12809 2/20 0.43
CACNA1C Q13936 2/20 0.43
HTR2C P28335 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11462470 0.95 SCN9A (0.46) PPARGPPARACYP3A4CYP3A5SLC6A4
SCHEMBL223867 0.86 SLC6A4 (0.44) PPARGPPARACYP3A4CYP3A5SLC6A4
SCHEMBL250835 0.86 SLC6A4 (0.44) PPARGPPARACYP3A4CYP3A5SLC6A4
SCHEMBL250952 0.86 SLC6A4 (0.44) PPARGPPARACYP3A4CYP3A5SLC6A4
SCHEMBL10629728 0.84 MTNR1A (0.44) KMT2ACYP2C19CYP1A2CYP2C9TSHR
SCHEMBL11598153 0.83 NR1H4 (0.47) MEN1KMT2ALMNANPC1RAB9A
SCHEMBL5797232 0.83 AR (0.47) PPARGCYP3A4SLC6A4SLC6A2SLC6A3
SCHEMBL15473214 0.83 SLC6A4 (0.44) PPARGPPARACYP3A4CYP3A5SLC6A4
SCHEMBL2090523 0.83 SLC7A5 (0.43) PPARGPPARACYP3A4CYP3A5SLC6A4
SCHEMBL22809555 0.81 SLC6A4 (0.50) PPARGPPARACYP3A4SLC6A4SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210808-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2023-07-06 US disclosed
US-20190192475-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2019-06-27 US disclosed
US-20170304254-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS JANSSEN PHARMACEUTICA NV (DE) 2017-10-26 US disclosed
US-9724322-B2 4-(phenoxyalkyl)thio)-phenoxyacetic acids and analogs JANSSEN PHARMACEUTICA N.V. (BE) 2017-08-08 US disclosed
US-20160199342-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2016-07-14 US disclosed
US-8518997-B2 4-(phenoxyalkyl)thio)-phenoxyacetic acids and analogs JANSSEN PHARMACEUTICA N.V. (BE) 2013-08-27 US disclosed
US-20120122988-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2012-05-17 US disclosed
US-8106095-B2 modulators of peroxisome proliferator activated receptors; treating diabetes, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cardiovascular diseases; dyslipidema; [4-[[2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]thio]-2-methylphenoxy]-acetic acid JANSSEN PHARMACEUTICA N.V. (BE) 2012-01-31 US disclosed
US-8106095-B2 modulators of peroxisome proliferator activated receptors; treating diabetes, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cardiovascular diseases; dyslipidema; [4-[[2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]thio]-2-methylphenoxy]-acetic acid JANSSEN PHARMACEUTICA N.V. (BE) 2012-01-31 US disclosed
EP-2100877-B1 4-((Phenoxyalkyl)thio)-phenoxyacetic acids and analogs JANSSEN PHARMACEUTICA NV (BE) 2012-01-25 EP disclosed
US-20100069496-A1 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2010-03-18 US disclosed
US-7635718-B2 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs JANSSEN PHARMACEUTICA NV (BE) 2009-12-22 US disclosed
US-7635718-B2 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs JANSSEN PHARMACEUTICA NV (BE) 2009-12-22 US disclosed
EP-2100877-A1 4-((Phenoxyalkyl)thio)-phenoxyacetic acids and analogs Janssen Pharmaceutica, N.V. (BE) 2009-09-16 EP disclosed
EP-1667964-B1 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS JANSSEN PHARMACEUTICA NV (BE) 2009-07-22 EP disclosed
US-20080085927-A1 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2008-04-10 US disclosed
US-20080085927-A1 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2008-04-10 US disclosed
US-7301050-B2 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs JANSSEN PHARMACEUTICAL N.V. (BE) 2007-11-27 US disclosed
US-7301050-B2 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs JANSSEN PHARMACEUTICAL N.V. (BE) 2007-11-27 US disclosed
US-4125732-A HYPOLIPIDEMIC AMERICAN CYANAMID COMPANY (US) 1978-11-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122988-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD PPARG 2/4885PPARA 1/4885CYP3A4 1163/4885
US-20100069496-A1 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD PPARG 2/4885PPARA 1/4885CYP3A4 1148/4885
US-20190192475-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD PPARG 2/4885PPARA 1/4885CYP3A4 1163/4885
US-20080085927-A1 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD PPARG 2/4885PPARA 1/4885CYP3A4 1148/4885
US-20230210808-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD PPARG 2/4885PPARA 1/4885CYP3A4 1163/4885
US-20170304254-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD PPARG 2/4885PPARA 1/4885CYP3A4 1163/4885
US-20160199342-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD PPARG 2/4885PPARA 1/4885CYP3A4 1163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.