Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TXNRD1 | Q16881 | 13/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553628 | 0.83 | SYK (0.43) | MERTKMAPTTXNRD1KMT2A | |
| SCHEMBL19172520 | 0.83 | LMNA (0.51) | MERTKMAPTALDH1A1RAB9AKMT2A | |
| SCHEMBL25289487 | 0.80 | MERTK (0.44) | MERTKMAPTTXNRD1GSRALDH1A1 | |
| SCHEMBL25637893 | 0.78 | BRD4 (0.47) | MERTKMAPTTXNRD1ALDH1A1HTT | |
| SCHEMBL4400500 | 0.77 | GSK3B (0.39) | MAPTALDH1A1TDP1 | |
| SCHEMBL25637792 | 0.75 | CYP1A2 (0.49) | MAPTALDH1A1HTTNPC1RAB9A | |
| SCHEMBL27199647 | 0.74 | TXNRD1 (0.41) | MERTKMAPTTXNRD1GSRALDH1A1 | |
| SCHEMBL10740434 | 0.73 | TXNRD1 (0.58) | MAPTTXNRD1GSRHTTRAB9A | |
| SCHEMBL29983153 | 0.73 | MERTK (0.49) | MERTKMAPTTXNRD1ALDH1A1HTT | |
| SCHEMBL15514986 | 0.73 | MERTK (0.49) | MERTKMAPTTXNRD1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |