Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.56 |
| ▸ | FPR2 | P25090 | 2/20 | 0.54 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.54 |
| ▸ | LIPE | Q05469 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.38 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018466 | 0.94 | MMP1 (0.54) | MMP1FPR2PROKR1LIPEMAPT | |
| SCHEMBL940600 | 0.89 | MMP1 (0.57) | MMP1FPR2PROKR1LIPEMAPT | |
| SCHEMBL7023309 | 0.83 | MMP1 (0.57) | MMP1FPR2PROKR1LIPEMAPT | |
| SCHEMBL941398 | 0.83 | MMP1 (0.54) | MMP1FPR2PROKR1LIPEMAPT | |
| SCHEMBL943749 | 0.83 | MMP1 (0.56) | MMP1FPR2PROKR1LIPEMAPT | |
| SCHEMBL942540 | 0.80 | MMP1 (0.58) | MMP1FPR2PROKR1LIPEMAPT | |
| SCHEMBL941502 | 0.80 | FPR2 (0.64) | MMP1FPR2PROKR1L3MBTL1TDO2 | |
| SCHEMBL7014611 | 0.80 | MMP1 (0.51) | MMP1FPR2PROKR1LIPETDO2 | |
| SCHEMBL940684 | 0.79 | MMP1 (0.52) | MMP1FPR2PROKR1LIPEMAPT | |
| SCHEMBL941419 | 0.79 | MMP1 (0.49) | MMP1FPR2PROKR1LIPEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370536-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| EP-1370556-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074767-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |
| WO-2002074750-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |