Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 9/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018996 | 1.00 | MAPT (0.50) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7124858 | 0.85 | ADRB1 (0.47) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7012719 | 0.82 | ALDH1A1 (0.49) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7012718 | 0.82 | ALDH1A1 (0.49) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7124863 | 0.82 | MAPT (0.46) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7122279 | 0.81 | MAPT (0.50) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7118226 | 0.79 | MAPT (0.50) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7118863 | 0.78 | ALDH1A1 (0.42) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7009709 | 0.78 | MEN1 (0.58) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7009713 | 0.78 | MEN1 (0.58) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972769-B1 | NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMA CO LTD (JP) | 2003-04-16 | — | — | EP | disclosed |
| US-6177454-B1 | ANTIDIABETIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| US-6048884-A | ANTIDIABETIC AGENTS; HYPOGLYCEMIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-04-11 | — | — | US | disclosed |
| EP-0972769-A1 | NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-01-19 | — | — | EP | disclosed |