Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 14/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019335 | 1.00 | XDH (0.43) | XDHMAPTALDH1A1HPGDLMNA | |
| SCHEMBL7022638 | 0.86 | XDH (0.41) | XDHMAPTALDH1A1HPGDLMNA | |
| SCHEMBL7022632 | 0.86 | XDH (0.41) | XDHMAPTALDH1A1HPGDLMNA | |
| SCHEMBL7015562 | 0.73 | XDH (0.44) | XDHMAPTALDH1A1HPGDLMNA | |
| SCHEMBL7015566 | 0.73 | XDH (0.44) | XDHMAPTALDH1A1HPGDLMNA | |
| SCHEMBL7024008 | 0.73 | ALDH1A1 (0.33) | ALDH1A1HPGDLMNA | |
| SCHEMBL7024004 | 0.73 | ALDH1A1 (0.33) | ALDH1A1HPGDLMNA | |
| SCHEMBL11208782 | 0.72 | XDH (0.47) | XDHMAPTALDH1A1HPGDLMNA | |
| SCHEMBL7022655 | 0.72 | — | — | |
| SCHEMBL7022651 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | claimed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |