Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7019451 | 1.00 | ALOX5 (0.53) | ALOX5TRPA1CYP3A4SLC1A3SLC1A2 | |
| SCHEMBL142208 | 0.88 | — | — | |
| SCHEMBL1219534 | 0.76 | ALOX5 (0.51) | ALOX5TRPA1CYP3A4PTGS1PTGS2 | |
| SCHEMBL25660312 | 0.76 | ALOX5 (0.47) | ALOX5SLC1A3SLC1A2SLC1A1HCAR2 | |
| Oxalic Acid SCHEMBL28194607 | 0.73 | LMNA (0.52) | ALOX5ADRB2 | |
| SCHEMBL5158897 | 0.72 | ALOX5 (0.47) | ALOX5TRPA1CYP3A4SLC1A3SLC1A2 | |
| SCHEMBL8882558 | 0.72 | ALOX5 (0.44) | ALOX5CYP3A4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL5929608 | 0.72 | ALOX5 (0.47) | ALOX5TRPA1CYP3A4SLC1A3SLC1A2 | |
| SCHEMBL3867319 | 0.72 | ALOX5 (0.44) | ALOX5TRPA1CYP3A4SLC1A3SLC1A2 | |
| SCHEMBL19494055 | 0.71 | SRC (0.50) | ALOX5TRPA1CYP3A4SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |